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Profhilo and comparable HA skin boosters
By Jessica | Wannabe Beauty Guru
Bestie, when we talk about a Profhilo “dupe,” I want us to look past the word hydration. Plenty of products contain hyaluronic acid, but that does not mean they have the same formula, behave the same way, or give us the same results.
Of the products we compared, Hyalace and REVS Pro 32 are the closest matches in formulation concept because they combine high and low molecular weight HA. AIOR 50, Regenovue Aquashine and Hanheal HA are other hydration options, with different formulas. [1–8]
What makes Profhilo different
Original Profhilo contains 64 mg of HA in a 2 mL syringe: 32 mg high molecular weight and 32 mg low molecular weight. Those terms describe the size of the HA chains, not the amount of product in the syringe. [1]
There is another piece of the story: Profhilo uses the patented NAHYCO thermal process to create stabilized hybrid cooperative complexes. Its performance cannot be reduced to simply mixing two molecular weights together. [1]
My take: “Similar formula” is a useful starting point. It is not proof of identical results or longevity.
Hyalace
The earlier Hyalace formula contained 32 mg high molecular weight HA plus 32 mg low molecular weight HA per 2 mL, or 64 mg total. The updated packaging shown on the Acecosm website lists 42 mg high molecular weight HA plus 42 mg low molecular weight HA and PN in a 2 mL syringe. That is 84 mg total HA, or 42 mg/mL (4.2%)—20 mg more per syringe, a 31.25% increase over the earlier formula. The older BNC catalog and BNC Baltic page still show 64 mg. [2,3,10,11]
Hyalace is my favorite. I find that its hydration noticeably lasts the longest for me, but it is also the most expensive of the Acecosm alternatives in this comparison per mL. I love splurging on it for vacations or holidays, when my skin gets the driest and I have less time for DIY skincare. Longer-lasting hydration is a blessing during those busy times! That is my personal experience, rather than a head-to-head clinical result.
The updated box shown on Acecosm explicitly names polynucleotides (PN), while its ingredient graphic lists sodium DNA. The PN amount is not stated on the front of the box. We use the packaging’s 84 mg HA total here, rather than the conflicting 90 mg retailer claim. [2,9,10]
I am super excited to try the updated Hyalace formula! It was already amazing for me, so the addition of more HA plus PN makes me even more excited. I think it could make it even better and even more worth the expense. That is my hope for the updated formula, rather than an improvement I have tested yet.
At the previously recorded Acecosm price of $160 for 2 mL, the product cost is $80.00 per mL before code Jessica10. Increasing the HA amount in the same 2 mL syringe changes its concentration, not the cost per mL, if the package price stays the same. More HA alone does not prove longer-lasting hydration or equivalence to Profhilo. [1,2]
REVS Pro 32
REVS also combines high and low molecular weight HA. Reanzen describes this product family as a hybrid HA complex made without chemical cross-linking agents. Acecosm lists a 2 mL syringe at $120, or $60.00 per mL before code Jessica10. [4,5]
REVS marketing is confusing. For our chart, we assume 32 mg of each HA weight per 2 mL. That split is not manufacturer-verified here. Acecosm’s wording of approximately 64 mg/mL conflicts with the 64 mg per 2 mL descriptions elsewhere; please do not treat them as interchangeable.
Other hydration alternatives
AIOR 50
AIOR 50 contains 50 mg of high molecular weight HA per 2 mL, equal to 25 mg/mL. Acecosm describes it as free from BDDE. Its listing does not document the same high-and-low combination as Profhilo. [6]
At $45 for a 2 mL syringe, it works out to $22.50 per mL before code Jessica10. I would describe it as a different HA hydration option, rather than a direct Profhilo formula match.
Regenovue Aquashine
The standard Regenovue Aquashine listing specifies 15 mg/mL of non-crosslinked HA. The package contains three 3 mL syringes, giving us 9 mL total. At $70 per package, that is $7.78 per mL before code Jessica10. [7]
For clarity, this comparison is about standard Aquashine. Aquashine Plus is a separate product and should not be substituted into this row. Acecosm’s standard Aquashine listing does not specify a Profhilo-style high-and-low blend.
Hanheal HA and the value question
Hanheal HA is more than a plain HA solution. Acecosm lists sodium hyaluronate at 1.7%, alongside a peptide complex. That corresponds to approximately 17 mg/mL when expressed as a weight-per-volume concentration. A 5 mL vial therefore contains approximately 85 mg of sodium hyaluronate. [8]
Acecosm describes the HA molecular weight as 1 million daltons. That is the chain size; it does not mean there is 1 million mg of HA! The listing does not document a dual-weight mixture like Profhilo. [8]
The box contains five 5 mL vials, or 25 mL total. At $110 per box, the cost is $4.40 per mL before code Jessica10. [8]
Every cost per mL in this article is BEFORE code Jessica10 discount. These are product-only calculations and exclude shipping, tax and treatment fees. Prices can change.
How I would read the price comparison
I love knowing what we are paying per mL, but price alone cannot tell us which product will suit our skin. Concentration, formulation, intended use and evidence matter too. A larger total amount of HA in a vial does not automatically mean a longer-lasting result.
My formula shortlist is Hyalace and REVS Pro 32. My broader hydration comparison includes AIOR 50, standard Aquashine and Hanheal HA. I am comparing their published descriptions here, not claiming a personal trial of every product or promising that they perform equally.
A quick safety note
I am not a doctor. This is educational information from one skincare-loving friend to another, not an injection guide or a recommendation to self-inject.
HA injectables can cause swelling, bruising, infection, nodules and vascular complications. “Non-crosslinked” does not mean risk-free. Product suitability and treatment decisions belong with a qualified licensed medical professional. [4]
Code Jessica10 is my affiliate code. I may earn a commission when you use it.
